L-proline is one of the 20 amino acids that are used to synthesize proteins by the human body. This amino acid is encoded in the human genetic code with the codons CCA, CCC, CCG and CCU. L-proline is the only proteinogenic amino acid that is a secondary amine, meaning that its amine nitrogen is bound to two alkyl groups. Virtually all of the proteins in the human body contain L-proline, and the only amino acids that are more abundant are alanine and glutamine. L-proline is especially important in the production of collagen, which is a primary component in skin, cartilage and bone.
The biosynthesis of L-proline uses the amino acid L-glutamate as a precursor, along with the enzymes glutamate 5-kinase and glutamate-5-semialdehyde dehydrogenase. The German chemist Richard Willstatter first synthesized proline in the laboratory in 1900 by reacting 1,3-dibromopropane with the sodium salt of diethyl malonate. The German chemist Hermann Emil Fischer isolated proline from casein in 1901 by using gamma-phthalimido-propylmalonic ester.
The biochemical actions of pure L-proline include weak agonism of the glycine receptors and some glutamate receptors. Plants also use proline to generate tissues such as pollen. Health supplements containing L-proline are often taken to support the growth of connective tissue.
|Chemical Name：||H-Pro-OH~(S)-Pyrrolidine-2-carboxylic acid|
|White crystalline powder|
|Appearance||White crystals or crystalline powder|
|Loss on drying,%||≤0.3|
|Heavy Metals (as Pb),%||≤0.001|
|Residue on Iginition,%||≤0.1|
|Arsenic (as As),%||≤0.0001|
|Other amino acids||Not detd.|
The Characteristics and Uses：
| Proline and its derivatives are often used as asymmetric catalysts in organic reactions. The CBS reduction and proline catalysed aldol condensation are prominent examples.|
L-Proline is an osmoprotectant and therefore is used in many pharmaceutical, biotechnological applications.
In brewing, proteins rich in proline combine with polyphenols to produce haze (turbidity).
Package and Transport：
|With round paperboard drum 25kgs per drum.|
|Kept in a light-proof, well-closed, dry and cool place. The expiry date is for two years.|